Data-intensive applications hosted in cloud platforms in fields such as bioinformatics, finance or healthcare are increasingly becoming multi-domain in nature. To augment local private cloud resources, these applications rely on multi-cloud resources that are remotely accessible (e.g., multiple public clouds, data archives, SaaS solutions from third-party vendors). Provisioning of such federated multi-cloud resources has been traditionally based on applications’ performance and quality of service (QoS) requirements. This talk will detail our project that aims to augment traditional cloud resource provisioning schemes through novel multi-cloud resource brokering scheme viz., OnTimeURB. Our approach formalizes applications' end-to-end security requirements to align security posture across multi-domain resources with heterogeneous policies. Our OnTimeURB broker design fosters end-to-end multi-domain security for cloud-based applications in bioinformatics and health information sharing that involves defining, formalizing and implementing security specifications along an application's workflow lifecycle stages.